The White House recently announced the launch of the National Nanotechnology Initiative’s inaugural National Nanotechnology Challenge, Nano4EARTH. This challenge is a call to action to mobilize stakeholders to identify and address barriers to widespread adoption of nanoscale solutions to the climate change crisis. The Nano4EARTH kick-off workshop will be a forum for the community to share ideas on specific opportunities that can be achieved – especially through multiagency coordination – in a 4-year time frame; to identify barriers to the scale-up, adoption, and dissemination of climate nanotechnologies; to establish metrics to monitor progress; and to build connections across the diverse community.